Estrone sulfate is actually the major active constituent in Premarin – pillsformedicine

Premarin is a type of treatment called Hormone Replacement Therapy (HRT) and contains the hormone oestrogen in the form known as conjugated oestrogens. This drug helps to relieve the discomfort many women feel during and after menopause, including symptoms such as “hot flushes”, sweating and vaginal dryness. It helps to prevent thinning of the bones (osteoporosis), which can cause fractures. It is also used to treat women where either the ovary does not function properly or has been removed. If your doctor thinks you will need to take oestrogens for a long time, including for the prevention of osteoporosis, he or she will have considered the benefits and risks of other treatments before prescribing Premarin for you.

Precautions :

Do not take this product if you have or have had any of the following medical conditions:Breast cancerEndometrial or cervical cancerAbnormal genital bleeding, which your doctor has not investigated.A problem with blood clots forming in your blood vessels, such as painful inflammation of the veins (thrombophlebitis) or the blockage of a blood vessel in the legs (deep vein thrombosis or DVT), or lungs (pulmonary embolism)Heart disease or strokeVery high blood pressure that is not properly controlledProblems with your breasts that your doctor has not investigatedLiver diseaseBlood clotting problems.
Drug interactions :

Tell your doctor or pharmacist if you are taking any of the following:

Herbal medicines containing St John’s WortSome medicines for epilepsy such as phenytoin, phenobarbitone and carbamazepineSome antibiotics and anti-infectives such as rifampicin, erythromycin and clarithromycinAnti-fungal agents such as ketoconazole and itraconazoleThyroid replacement therapyCorticosteroids, such as dexamethasoneRitonavir for the treatment of HIV infectionCyclosporin used to prevent organ rejection.
Side effects :

Tell your doctor if you notice any of the following and they worry you:

Abnormal genital bleeding or spotting (if bleeding is heavy check with your doctor as soon as possible)Tender, painful or swollen breasts, or secretions from the breastsPeriod-like pain or pelvic painVaginal discharge or change in secretionsVaginal thrushStomach painStomach swelling or passing windNausea or vomitingHeadache or migraineLoss of hearingLoss of memoryIrregular, rapid jerky movementsDizzinessDepression or anxietyProblems sleeping or sleepinessModiness or irritabilityChanges in sex driveSwelling of the lower legs, ankles or fingers
Storage:

Store at room temperature. Protect from heat, light and moisture. Keep away from reach of children.

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